27th LC/MS Montreux Symposium Montreux, Switzerland, November 10–12, 2010 Instructions The entire abstract should not exceed one A4 page with margins set at top 4 cm, bottom 3 cm and left/right 3 cm. The title should be in 14 pt Arial Bold, upper and lower case letters. The authors should indicate First Name and Surname. The Presenting Author should be underlined. All text should be in Arial 11 pt and single line spacing. Special characters, symbols, Greek characters, mathematical formulae and figures should be confined to set of fonts that come with the standard distribution of Microsoft Word. All figures in abstracts must be in black and white. Logo's of institutions or companies are not allowed. The abstract file should not exceed 8 MB The Scientific Committee reserves the right to accept or reject papers, and to assign them to oral or poster contribution. This is the list of posters of the 25th LC/MS Montreux Symposium PDF 001 Kim Alving, Genzyme Corporation/Analytical Research and Development, Waltham, USA Deubiquitination Assay Development of Intact Protein Quantitation by Mass Spectrometry for High Throughput Screening 002 Ekaterini Antoniadou-Vyza, University of Athens, Athens, GR Elucidation of Piroxicam Photo-induced Decomposition Pathways by a New Specific HPLC and LC-MS Method 003 Svetlana Appolonova, Moscow Anti-Doping Centre, Moscow, RU Enhanced Detection and Structural Elucidation of 3-Oxo¬steroids Derivatives with Hydroxyammonium Chloride Using HPLC- MS/MS 004 Svetlana Appolonova, Moscow Anti-Doping Centre, Moscow, RU Investigation of Pharmacokinetics and Metabolism of a Novel Original Neuroleptic Dilept by Chromatography and Mass Spectrometry Techniques 005 Giancarlo Aquino, Chiesi Farmaceutici S.p.A., Parma, IT CHF 4226 in Vitro and in Vivo Phase II Metabolism. A Mass Spectrometric Investigation of Glucuronidation Pathways in Different Species 006 Craig R. Aurand, Supelco Sigma/Aldrich, Bellefonte Pa, USA Extraction of Propranolol and 4-hydroxy Propranolol Metabolite from Rat Plasma Using Biocompatible Solid Phase Micro Extraction (SPME) 007 Graig R Aurand, Sigma Aldrich/Supelco, Bellefonte Pennyslvania, USA Selective Depletion of Phospholipid Interference Utilizing Hybrid SPE Technology 008 Simona Barattè, Accelera/Nerviano Medical Sciences, Nerviano (Milan), IT Risk Associated to Study Samples Bioanalysis Using LC-MS/MS Methods 009 Iain Beattie, AstraZeneca R&D Charnwood, Loughborough, UK Metabolite Identification and Quantitation Using the LTQ Orbitrap 010 Dave Bell, Supelco /Sigma-Aldrich, Bellefonte, USA Aqueous-Normal Phase/HILIC in LC-MS Separations:  Retention Mechanisms and Their Impact on Retention and Selectivity 011 Alex Berhitu, Spark Holland BV, Emmen, NL Simultaneous Determination of Glyphosate and Glufosinate in Surface Water by Online-SPE LC-MS/MS Analysis 012 Alex Berhitu, Spark Holland BV, Emmen, NL Determination. of Quinolones and Macrolides in Honey by Online-SPE LC-MS/MS Analysis 013 Magdalena Biesaga, University of Warsaw, Department of Chemistry, Warsaw, PL Determination of Phenolic Compounds in Food Samples by HPLC-MS/MS 014 Magdalena Biesaga, Department of Chemistry and Industrial Chemistry, Università di Pisa, Pisa, IT Historical and Archaeological Textiles: an Insight on Degradation Products of Wool Yarns 015 Ron Bonner,MDS Sciex, Concord, CA New Applications of QTRAP Systems in Metabolite ID 016 Andries Bruins, University of Groningen, Groningen , NL Mechanistic Aspects of Electrochemical Oxidation of Tyrosine and Tryptophan Containing-tripeptides by Electrochemistry-Mass Spectrometry 017 Brigitte Buscher, TNO Quality of Life, Zeist, NL In Vivo Microdialysis in Rats: LC-MS/MS Analysis of Microdialysis Samples 018 Joanna Caulfield, Biotage GB Limited, Cardiff, UK Evaluation of Recoveries and Extract Cleanliness Using Mixed-mode Cation Exchange SPE Columns for Basic Analyte Extraction 019 Eva Choong, CHUV, UBPC laboratory, Prilly-Lausanne, CH Simultaneous Determination and Quantification of 7 Psychotropic Drugs and 4 Metabolites in Human Plasma by HPLC-MS for Therapeutic Drug Monitoring 020 Núria Cortés, CID-CSIC, Barcelona, ES Accurate Mass Measurement on ESI-MS: Capabilities of different mass analyzers 021 Leon Coulier, TNO Quality of Life, Zeist, NL Lipidomics in Studies of Lifestyle Associated Diseases. Part 1: Analytical Methods 022 Leon Coulier, TNO Quality of Life, Zeist, NL Simultaneous Determination of Endogenous Deoxynucleotides and Phosphorylated Nucleoside Reverse Transcriptase Inhibitors in Peripheral Blood Mononuclear Cells Using Ion-pair LC-MS/MS 023 Leon Coulier, TNO Quality of Life, Zeist, NL Quantitative Profiling of Bile Acids in Biofluids and Tissues Based on Accurate Mass High Resolution LC-FT-MS: Compound Class Targeting in a Metabolomics Workflow 024 Viktor Cvilink, Faculty of Pharmacy, Charles University, Hradec Králové, CZ LC-MS/MS Identification of Benzimidazole Anthelminthics Metabolites Formed ex Vivo by Dicrocoelium dendriticum 025 Joseph J. Dalluge, Cargill Incorporated, Excelsior, USA LC-Tandem Mass Spectrometry of Glycolytic and Pentose Phosphate Intermediates: Deconvolution of Coeluting Structural Isomers Based on Unique Product Ion Ratios 026 Gert De Boeck, NICC, Brussel, BE High Throughput Analysis of Amphetamines in Blood and Urine with On-line Solid-Phase Extraction-Liquid Chromatography-Tandem Mass Spectrometry 027 Alain Deroussent, Mass Spectrometry Platform IFR54, Villejuif Cédex, FR Evaluation of in Vitro Metabolism Pathways of Dimethylated Ifosfamide Analogs in Rat and in Human Using HPLC-MS/MS 028 Giuseppe Di Landa, ENEA, Portici, IT Determination of four Tobacco-Specific Nitrosamines (TSNAs) in Mainstream Cigarette Smoke Condensate by a Multi-step Solid Phase Extraction Procedure and Liquid Chromatography with Single Quadrupole Mass Detection 029 Marina Dikunets, Moscow Anti-Doping Centre, Moscow, RU Differentiation of Ephedrines by Chemical Derivatization and Electrospray Tandem Mass Spectrometry 030 Marina,Dikunets, Moscow Anti-Doping Centre, Moscow, RU Metabolism of 2-ethyl-6-methyl-3-oxypyridine in human: effect of Mexidol administration on the urinary 6_-OH-cortisol/cortisol and cortisol/cortisone ratios 031 Benedicte Duretz, Thermo Fisher Scientific, Courtaboeuf, FR A Quantitative General Unknown Screening Method for Drugs and Toxic Compounds in Urine Using Liquid Chromatography-Mass Spectrometry 032 Walid Elbast, Synexel Research International, Poitier, FR Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometric (LC/ESI-MS/MS) Method for the Determination of 1_,25-Dihydroxyvitamin D3 (Calcitriol) in Human Plasma 033 Erik Emke, Kiwa Water Research, Nieuwegein, NL Development and Optimization of a Method to Quantify Fullerenes C60 in Water with High Performance Liquid Chromatography LTQ FT Orbitrap Mass Spectrometry 034 Stéphane Etheve, DSM Nutritional Products, Basel, CH Validation of an On-line Extraction LC-MS Method for the Determination of Z-Ligustilide (LIG) and Senkyunolide A (SKD) in Plasma/serum 035 Carlos Fernandes-Lopes, Laboratorios Bial, S.Mamede do Coronado, PT Determination of Eslicarbazepine Acetate, a New Antiepileptic Drug and Its Metabolites in Mouse Plasma Using a Validated Method 036 Nicolas Fraysse, Thermo Fisher Scientific, Dreieich, DE Environmental Analysis of Minoxidil in Water and Tea Extracts by LC-FAIMS-MS/MS 037 Mattias Fredriksson, Mid Sweden University, Sundsvall, SE An Automatic Peak Finding Method for Liquid Chromatography - Mass Spectrometry Data 038 Ali Gharib, Islamic azad University, Mashhad, IR Analytical Methods in the Synthesis of Phenylsalicylates 039 Ali Gharib, Islamic azad University, Mashhad, IR Instrumental Analytical Methods in Catalytic symthesis of _-butyrolactone, _-caprolactone 040 Richard Gössl, DSM Nutritional Products Ltd., Basel, CH Dopant Assisted LC-APPI-MS/MS Determination of Vitamin D3 and its 25-Hydroxy Metabolite: A New Assay for Biofluids 041 Warunee Hanpithakpong, Mahidol University, Bangkok, TH A Simple and Sensitive 96 Wellplate Solid Plate Extraction with Mass Spectrometric Method to Determine Azithromycin in Human Plasma 042 Stephanie N. Harden, Waters AG, Baden-Dättwil , CH An Assessment of the Quality and Precision of Therapeutic Antibody LC/MS Data Acquired and Processed using Automated Workflows 043 Juris Hmelnickis, Joint stock Company "Grindeks", LT Development of an LC/MS/MS Procedure for Determination of Impurity Content in Mildronate Using Hydrophilic Interaction Chromatography 044 Julie Horner, Thermo Fisher Scientific, San Jose, USA PIF: Precursor Ion Fingerprinting - Searching for Precursor Identifying Fragments Using LC-MSn 045 Yingying Huang, Thermo Fisher Scientific, San Jose, USA Intelligent Workflows for Metabolite Screening and Biotransformation Characterization Using MSM on an LTQ Orbitrap 046 Gustaf Hulthe, AstraZeneca R&D Mölndal, Mölndal, SE Comparison Between Four Atmospheric Pressure Ion Sources for MS: DART, APPI, APCI and ESI 047 Christophe Husser, F. Hoffmann-La Roche AG, Basel, CH Benefits and Limitations of UPLC for Metabolite Profiling of Drugs Using Radioactive Detection Combined with LC-MS/MS 048 Emilien Jamin, INRA, UMR 1089 Xénobiotiques , Toulouse, FR Sequence Selectivity of DNA Adduction by a Heterocyclic Aromatic Amine (PhIP) 049 Willy Janssens, Johnson & Johnson Pharmaceutical Research & Development, Beerse, BE The Introduction of a Direct Analysis in Real Time (DART) Interface in API Development. 050 Bernard Jeanbaptiste, SGS Life Sciences, Wavre, BE LC/MS-MS Method for the Determination of Beclomethasone Dipropionate and Beclomethasone-17-Monoproprionate in Human Plasma 051 Bernard Jeanbaptiste, SGS Life Sciences, Wavre, BE Sensitive LC/MS-MS Method for the Determination of 22R and 22S Budesonide Epimers in Human Plasma 052 Bernard Jeanbaptiste, SGS Life Sciences, Wavre, BE LC/MS-MS Method for the Determination of Progesterone in Heparinised Human Plasma 053 Bernard Jeanbaptiste, SGS Life Sciences, Saint-Benoit Cedex, FR LC-MS/MS Method for the Determination of Cortisol and 11-Deoxycortisol in Human Plasma (EDTA) 054 Bernard Jeanbaptiste, SGS Life Sciences, Saint-Benoit Cedex, FR LC-MS/MS Method for the Determination of Prednisone and Prednisolone in Heparinised Human Plasma 055 withdrawn 056 Charles Jolliffe, IONICS Mass Spectrometry Group, Bolton, USA Plume containment for High Flow Electrospray using Multiple Coaxial Flows 057 Michael D. Jones, Waters Corporation, Milford , USA A Workflow Approach for the Identification and Structural Elucidation of Impurities in Quetiapine Fumarate Drug Substance 058 Russell Jones, Pfizer Global R&D, Sandwich, UK Extended UPLC Gradients for Rapid Metabolite Identification 059 Jurre Kamphorst, Leiden University, LACDR/ABS, Leiden, NL Feasibility of Electrodialysis as a Fast, Selective, and Concentrating Sample Preparation Method for the Profiling of Low Abundant Peptides in Biofluids 060 Piotr Kasper, Leiden University, LACDR/NMC, Leiden, NL Analysis of High Resolution Fragmentation Trees for Discerning Isomeric Metabolites 061 Maya Kochman, Leiden University, LACDR/NMC, Leiden, NL Reducing Ion Suppression by Using Comprehensive LCxLC 062 Rudolf Köhling, Sigma-Aldrich Production CH, Buchs, CH Highly Sensitive Anion Detection with LC/MS supported by Di- and Tricationic Reagents 063 Emile Koster, Spark Holland BV, Emmen, NL Serum Interference Reduced During the Analysis of Atenolol by Means of Mixed Mode Online-SPE LC-MS/MS 064 Emile, Koster, Spark Holland BV, Emmen, NL A Systematic Online SPE-LC-MS/MS Method Development Strategy for the Analysis of Biological Samples 065 Sook-Yeon Lee, Korean Food and Drug administration, Seoul, Kr Determination of Grayanotoxins in Wild Honey 066 Natchanun Leepipatpiboon, Chulalongkorn University, Bangkok, TH Rapid Determination of Phenoxy Acid Residues in Rice by Modified QuEChERS Extraction and UPLC-MS/MS 067 Jan A. van Leerdam, Kiwa Water Research, Nieuwegein, NL Strategy for the Screening and Identification of Polar Compounds in Water Samples with LC-MS/MS Accurate Mass Measurements 068 Jan A. van Leerdam, Kiwa Water Research, Nieuwegein, NL Determination of Polar 1-H-Benzotriazoles and Benzothiazoles in Water Samples by Solid-Phase Extraction and High Performance Liquid Chromatography LTQ FT Orbitrap Mass Spectrometry 069 Gaëla Leroy, CAE-Veolia Environnement, Saint Maurice Cedex, FR Multiresidue Analysis of Pesticides by LC/MS-MS in Water Using On*line and Off-line Solid Phase Extraction 070 Jiajie Li, Leiden University, LACDR/ABS, Leiden, NL Single Cell Mass Spectrometry 071 Peter Lindenburg, Leiden University, LACDR/ABS, Leiden, NL Analytical Liquid-liquid Electroextraction to Enhance the Detection Limits of Peptides 072 Louis Maljers, Thermo Fisher Scientific, San Jose, USA Quantification of Insulin at Microdosing Levels Using LC-MS/MS 073 Leao Martins, Dpto. Química Analítica y Alimentaria. Facultad Química, Universidad de Vigo, Vigo, ES Immunoaffinity Chromatography and LC-MS Strategies for the Identification of Microcystins in Blue-Green Algae. 074 Joanna Mather, Waters Corporation, Milford, USA Simultaneous Acquisition of Qualitative and Quantitative MS Data Coupled with UPLC as a Tool for Bioanalytical Method Development 075 Yang Mauron, Swiss Institute of Bioinformatics, Geneva, CH SmileMS; A new Mass Spectrometry Based Identification Platform for Small Molecules 076 Shane McDonnell, Thermo Fisher Scientific, Hemel Hempstead, UK An On-line Turbulent Flow Extraction LC-MS/MS Screen for the Quantitative Analysis of Multiple Classes of Illicit Drugs in Plasma, Urine and Oral Fluid 077 Graham A. McGibbon, Advanced Chemistry Development, Inc., Toronto, CA Automating Software Analysis of Component Isotope Cluster Mass Differences in LC/MS Datasets 078 Nathalie Mesplet, Sanofi-Aventis, Sisteron, FR Identification of over TTC-impurities in DS and DP by LC/MSn and HS/GC/MS 079 Toshiyuki Mikami, Leiden University, LACDR/ABS, Leiden, NL Profiling of Amine-Containing Metabolites by SCX/HILIC 080 withdrawn 081 withdrawn 082 Leen Mortier, Clinical Laboratory, Virga Jesse Hospital, Hasselt, BE Urinary Free Cortisol by Liquid Chromatography Tandem Mass Spectrometry 083 Leen Mortier, Clinical Laboratory, Virga Jesse Hospital, Hasselt, BE Measurement of 25-hydroxy Vitamin D in Blood by Liquid Chromatography Tandem Mass Spectrometry and Comparison to a Radioimmunoassy Method 084 Moira Municchi, Molteni Therapeutics, Sienna, IT Photochemistry Study of RLP068, a Cationic Tetrasubstitued Phthalocyanine Derivative as Sensitizer for Antimicrobial Photodynamic Therapy 085 Dennis Nagtalon, Thermo Fisher Scientific, San Jose, USA A Novel Software Algorithm for the Quantitative Calculation of Mass Spectral Ion Intensites for Inborn Errors of Metabolism 086 Lars Neudert, MDS Pharma Services AG, Fehraltorf, CH Assessment of Extract Cleanliness Using Different On-Line Clean Up Selectivities for a Turbulent Flow Chromatography (TFC)-MS/MS Method for the Determination of a Common Decongestant Agent in Human Plasma 087 Pekka Östman, University of Helsinki, Dept. of Forensic Medicine, Helsinki, FI Comprehensive Screening for Drugs in Multiple Tissues by LC/TOFMS 088 Julian Philips, Thermo Fisher Scientific, San Jose, USA Improved Coverage in Global Proteomics Survey Experiments by Decreasing Cycle Time on a Linear Ion Trap Mass Spectrometer. 089 Rossella Pisano, Accelera/Nerviano Medical Sciences, Nerviano (Milan), IT Use of LC-MS for Quantitative Analysis in Preclinical Formulations 090 Robert Plumb, Waters Corp, Milford, USA A Rapid Sub 1 minute LC/MS/MS Assay for Physicochemical properties and p450 Inhibition-Induction Screening Using Sub 2um Particle LC 091 Simona Rizea Savu, 3S-Pharmacological Consultation and Research GmbH, Harpstedt, DE Application of HPLC-MS/MS and ICP/MS to the Identification and Quantitation of Clopidogrel Metabolites in Plasma Samples 092 Sarah Robinson, Thermo Fisher Scientific, Hemel Hempstead, UK Expediting Targeted Protein Quantification Method Development Using a Triple Quadrupole Mass Spectrometer: Software and Hardware Tools to Address Hypothesis-Based and Bioinformatics-Based Approaches 093 Miguel Rojas, Leiden University, LACDR/NMC, Leiden, NL Molecular Formula Dereplication Based on MSn 094 Daniel Root, Waters Corporation, Milford, USA The Search for the "Real Thing", Hoodia gordonii content in Commercially Available Diet Supplements by UPLC/MS 095 Paul J. Russell, Unilever Safety 7 Environmental Assurance Centre, Bedford, UK Determination of Steroid Glycosides in Hoodia Gordonii by Ultra Performance Liquid Chromatography (UPLC) with Photo-Diode Array and Data Dependant Linear Ion Trap Mass Spectrometric Detection 096 Rana Said, Farmakologiska laboratoriet, Klinisk farmakologi Karolinska Universitetssjukhuset, Stockholm, SE Whole Blood Analysis for Pharmacokinetics Studies Utilizing MEPS-LC-MS\MS 097 Gaurang Shah, Veer Narmad South Gujarat University, Surat, Gujarat, IN Estimation of Artesunate and its Metabolite Dihydroartemisinin in Human plasma Using LC-MS/MS in Positive Mode 098 Sandeep Sharma, Lambda Therapeutic Research Limited, Ahmedabad, Gujarat, IN Determination of Ibandronate in Human Plasma by Solid Phase Extraction on Column Methylation and LC-MC/MS 099 Yang Shi, Thermo Fisher Scientific, Franklin, USA Bioanalytical Assay for Neurotransmitters in Whole Blood by LC-MS/MS 100 Shanna Shi, Leiden University, LACDR/ABS, Leiden, NL Amino Acid Analysis by UPLC-MS/MS Using Accq-Tag Derivatization for the Study of the CSF Metabolome as Biomarker Compartment for CNS Disorders 101 Luigi Silvestro, 3S-Pharmacological Consultation and Research GmbH, Harpstedt, DE Development and Validation of a Capillary Electrophoresis-MS/MS Method to Quantitate Citalopram Enantiomers in Plasma Samples of Pharmacokinetic Studies; Comparison to HPLC-MS/MS 102 Markus Smolny, Novartis Pharma AG, Basel, CH Characterization of a Single-chain Fragment Monoclonal Antibody 103 Gunnar Stenhagen, AstraZeneca R&D Mölndal, Mölndal, SE Quantitative Bio-Analysis Using Fast LC and TOF Mass Spectrometer 104 Andreas Steurer, Inovalab AG, Reinach, CH A Rapid and Sensitive LC-MS/MS Method for the Quantification of Cyclosporin A with Novel Column Materials 105 Emmanuel Strahm, Swiss Laboratory for Doping Analysis, Epalinges, CH Analytical Strategy for the Quantification of Endogenous Steroids Glucuronide and Sulfate Metabolites Using LC-MS/MS 106 Mark A. Szewc, Thermo Fisher Scientific, Somerset, USA Metabolite Screening and Structural Elucidation Using a New Generation of Triple Quadrupole Mass Spectrometers 107 Isabela Tarcomnicu, Pharma Serv International, Bucharest, RO High-throughput HPLC-MS/MS Method to Determine Ibandronate in Human Plasma for Pharmacokinetic Applications 108 James Taylor, Aptuit Ltd, Edinburgh, UK Effect of In-Source Mobile Phase Composition on Analyte Sensitivity 109 James Taylor, Aptuit Ltd, Edinburgh, UK Column Carryover: Causes and Prevention 110 Alexander Tempels, Leiden University, LACDR/ABS, Leiden , NL Searching Metabolite Markers for Predictive Diagnostics for Diabetic Nephropathy 111 Christine Thompson, Pfizer Global Research and Development, Kent, UK Structural Elucidation of Impurities in Drug Substances Using Smart Formula 3D 112 May Tom-Moy, Agilent Technologies, Santa Clara, USA Subcellular Fractionation for Subcellular Proteomics Using Asymmetric Field Flow Fractionation (aFFF) 113 Francisco Torrens, Universitat de València, Valencia, ES Calculation of the Partition Coefficient of Lysozyme 114 Jan Van Dam, Technical University Delft, Delft, NL Quantitative Analysis of Metabolites in Complex Biological Samples Using Ion Pair Reversed Phase Liquid Chromatography Isotope Dilution Tandem Mass Spectrometry 115 Heiko van der Linden, Leiden University, LACDR/ABSm Leiden, NL Voltage-Flow Rate Tuning of Nanoelectrospray Mass-Spectrometry 116 Robert Van Ling, Dionex Corporation, Amsterdam, NL Automated Gel-Free Analysis Including Digestion Applied as a Top-Down Workflow in Proteomics 117 Herman Van Wietmarschen, Leiden University, LACDR/ABS, Leiden , NL Systems Biology Guided By Traditional Chinese Medicine Reveals New Diagnostic Markers For Rheumatoid Arthritis 118 Elwin Verheij, TNO Quality of Life, Zeist, NL Fluxomics: Application of Stable Isotopes to Study the Effect of Body Fat Distribution on the Physiological Response to a Dietary Fat Intervention 119 Laurian Vlase, University Iuliu Hatieganu, Cluj-Napoca, RO Determination of Carbamazepine and its Active Metabolite in Human Plasma by High-Performance Liquid Chromatography with Mass Spectrometry Detection 120 Michael Vogeser, University of Munich, Munich. DE Sample Preparation for Liquid Chromatography-Tandem Mass Spectrometry Using Functionalized Ferromagnetic Micro-Particles 121 Robert Voyksner, LCMS Limited, Raleigh, USA Addressing the Challenges in Quantifying PFOA and PFOS by LC/MS/MS 122 Marcel de Vries, UMC Groningen, Groningen, NL Metabolomics Modeling and Analysis of the Metabolic Switch in S. Coelicolor 123 Dave Warburton, Biotage GB Limited, Cardiff, UK Extraction of Corticosteroids from Urine:- Method Optimization using EVOLUTE ABN prior to LC-MS/MS Analysis. 124 Koko Wei, TNO Quality of Life, Zeist, NL Fast Lipid Analysis by Nanospray Chip-Based MS 125 Johan Wernevik, AstraZeneca R & D Mölndal, Mölndal, SE LDTD-MS/MS and LC-MS/MS Comparison for High Throughput IC50 Determination of 2A6, 2B6, 2C9, 2C19, 2D6 and 3A4 in Human Liver Microsomes 126 Daniel J. Weston, AstraZeneca R&D Charnwood, Loughborough, UK Rapid Evaluation of Metabolic Viability for In-Vitro Incubations using Direct Analysis in Real Time (DART-MS) as a Novel Alternative to LC_UV/MS Methodologies 127 Andre Wetter, Bruker Daltonics, Faellanden, CH Statistical Evaluation of the Benefit of Combined Use of Accurate Mass and Isotopic Pattern 128 Andre Wetter, Bruker Daltonics, Faellanden, CH Analyzing Plasma Proteome with Electron Transfer Dissociation and Proton Transfer Reaction 129 Andre Wetter, Bruker Daltonics, Faellanden, CH A Simple and Efficient Concept for ETD and PTR in a 3D Ion Trap 130 Andre Wetter, Bruker Daltonics, Faellanden, CH Differential Proteome Analysis using Targeted Label-Free and SDS-PAGE ICPL Workflows 131 Andre Wetter, Bruker Daltonics, Faellanden, CH Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17 132 Andre Wetter, Bruker Daltonics, Faellanden, CH Detailed Annotation of Qualitative Differences in Recombinant Protein Samples by Top-Down LC-MALDI-reISD - A QC Exercise 133 Andre Wetter, Bruker Daltonics, Faellanden, CH Improved Sensitivity for PAH Analysis with GC/APLI-MS 134 Andre Wetter, Bruker Daltonics, Faellanden, CH Label-free LC-MS Differential Proteome Analysis 135 Andre Wetter, Bruker Daltonics, Faellanden, CH Combination of Atmospheric Pressure Ionisation Techniques in a Single Source 136 Andre Wetter, Bruker Daltonics, Faellanden, CH Resolving Unresolved Complex Mixtures: Offline Coupling of Liquid Chromatography and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry 137 Andre Wetter, Bruker Daltonics, Faellanden, CH Top-down PTM Characterization by Consecutive ETD and PTR 138 Andre Wetter, Bruker Daltonics, Faellanden, CH Multi-Target Screening of 200 Pesticides in a Single LC/MS Run by exact Ion Traces in an ESI-TOF 139 Andre Wetter, Bruker Daltonics, Faellanden, CH Profiling and Fingerprinting of Beverages using LC/MS and NMR 140 Andre Wetter, Bruker Daltonics, Faellanden, CH TLC-MALDI Imaging Analysis of Phospholipids 141 Dave Wheatley, Wyeth Research UK, Gosport, UK The Use of LC-MS in a Forced Degradation Study of a Novel Molecule Leading to the Understanding of Longer Term Drug Product Behavior 142 Lubbe Wiesner, University of Cape Town, Cape Town, ZA Antimalarial Study of Compounds Isolated from Xerophyta species 143 Donna L. Wilson, Thermo Fisher Scientific, San Jose, USA Metabolomic Screening of Human Plasma Using U-HPLC Coupled to a Bench-top Non-hybrid Orbitrap Mass Spectrometer with HCD Fragmentation 144 Rebecca E. Wittrig, Restek Corporation, Bellefonte, PA, USA Enhanced Selectivity Through pi-pi Interactions Using a Unique Biphenyl Stationary Phase 145 Simon Wood, MDS Pharma Services AG, Fehraltorf, CH Evaluation and Comparison of the Matrix factor in Various Mass Spectrometric Ionisation Modes for the Determination of Exemestane in Human Plasma 146 Jason Wrigley, Biotage GB Limited, Cardiff, UK Generic Extraction Protocols Using Supported Liquid Extraction (SLE+) Prior to LC-MS/MS Analysis. 147 Yang Yang, Astrazeneca, Södertälje, SE Implementation of Chemometric Data Evaluation of UPLC-ToFMS Data, Routine Approach for Monitoring Batch-to-Batch Variations of Drug Substances 148 Andrea Zenker, Agilent Technologies, Inc., Santa Clara, USA A Strategy for Increased Metabolome Coverage in Erythrocytes Using a Single LC Chromatographic Method with Multi-Modal LC/MS Detection 149 Jerry Zweigenbaum, Agilent Technologies, Inc., Wilmington, USA High Sensitivity High Resolution LC/TOF MS for Screening and Identification of Target and Non-Target Pesticide Residues in Food and the Environment 150 Christian Zwiener, Uni Karlsruhe, EBI, Water Chemistry, Karlsruhe, DE Compound Class-specific Analysis of Acidic Metabolites of Anaerobic Degradation by Neutral Loss Scans LAST MINUTE POSTERS 151 Jordan Gonçalves, Biotec Centre, Orleans, FR Set Up and Development of a Liquid Chromatography Coupled to Tandem Mass Spectrometry Method for the Quantification of Pregnenolone and MAP4343 in Dog Plasma Abstract Submission Deadline Oral –lectures Vendor Hightlight Session Poster –presentations form to download T Should you require any further information, please do not hesitate to contact the chairman at the following address: Prof.Dr. Jan van der Greef Leiden University, LACDR P.O. Box 9502 NL–2300 RA Leiden The Netherlands Tel: 0031 71 527 4220 Fax: 0031 71 527 4277 E-mail: